Thrombotic Events and Pentosidine in Hemodialysis
Identifieur interne : 002767 ( Main/Exploration ); précédent : 002766; suivant : 002768Thrombotic Events and Pentosidine in Hemodialysis
Auteurs : W. D. Schwing [États-Unis] ; P. Erhard [États-Unis] ; C. Holloman [États-Unis] ; K. Weigel [États-Unis] ; S. Blankshaen [États-Unis] ; J. Anderson [États-Unis] ; C. Siegel [États-Unis] ; D. Seaman [États-Unis] ; J. Valente [États-Unis] ; P. Deoreo [États-Unis] ; M. F. Weiss [États-Unis]Source :
- Hemodialysis International [ 1492-7535 ] ; 2004-01.
Abstract
Poorly functioning dialysis access, whether graft or AV fistula, is a contributor to decreased efficiency of dialysis. Thrombosis results in the need for surgery and increases patient suffering. Objectives: To determine whether an advanced glycation end product (AGE), pentosidine, might serve as a marker of disease activity and thrombosis of dialysis access. These results were obtained during the blinded phase of a study to evaluate the efficacy of the antioxidant vitamin E in preventing vascular access thrombotic events. Methods: Twenty‐six patients had blood drawn and access flow evaluated initially and at intervals for up to 1.5 years. In the study design, participants received either 800 IU vitamin E daily by mouth or identical placebo capsules. Blood plasma was examined to determine pentosidine content at baseline and every 3 m. Patients with an access flow of <800 mL/min were referred to a surgeon for evaluation. Access flow was evaluated by using the transonic flow meter and the saline release method. When sequential double dialyzers were used, saline injection method was applied post dialyzers, but before the venous drip chamber. Results: Mean initial level of pentosidine before the administration of vitamin E was 20.22 pmol/mg (range 5.04–59.62 pmol/mg). During the study period, 5 patients had procedures related to thrombosis performed on their accesses. Blood drawn before the thrombotic event showed an increase above baseline of 6.87 ± 15.47 (range −5.9 to +33.7 pmol/mg). Patients without events showed a mean decrease of 9.7 ± 12.24 pmol/mg pentosidine (p < 0.02). Conclusion: An increase in levels of pentosidine was associated with clotting of hemodialysis access. This change may reflect the effects of oxidative stress and/or thrombus formation. As these data are gathered from an ongoing double‐blinded study, the effect of vitamin E on thrombus formation and pentosidine levels has not yet been ascertained.
Url:
DOI: 10.1111/j.1492-7535.2004.0085f.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000804
- to stream Istex, to step Curation: 000799
- to stream Istex, to step Checkpoint: 001239
- to stream Main, to step Merge: 002776
- to stream Main, to step Curation: 002767
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Thrombotic Events and Pentosidine in Hemodialysis</title><author><name sortKey="Schwing, W D" sort="Schwing, W D" uniqKey="Schwing W" first="W. D." last="Schwing">W. D. Schwing</name></author><author><name sortKey="Erhard, P" sort="Erhard, P" uniqKey="Erhard P" first="P." last="Erhard">P. Erhard</name></author><author><name sortKey="Holloman, C" sort="Holloman, C" uniqKey="Holloman C" first="C." last="Holloman">C. Holloman</name></author><author><name sortKey="Weigel, K" sort="Weigel, K" uniqKey="Weigel K" first="K." last="Weigel">K. Weigel</name></author><author><name sortKey="Blankshaen, S" sort="Blankshaen, S" uniqKey="Blankshaen S" first="S." last="Blankshaen">S. Blankshaen</name></author><author><name sortKey="Anderson, J" sort="Anderson, J" uniqKey="Anderson J" first="J." last="Anderson">J. Anderson</name></author><author><name sortKey="Siegel, C" sort="Siegel, C" uniqKey="Siegel C" first="C." last="Siegel">C. Siegel</name></author><author><name sortKey="Seaman, D" sort="Seaman, D" uniqKey="Seaman D" first="D." last="Seaman">D. Seaman</name></author><author><name sortKey="Valente, J" sort="Valente, J" uniqKey="Valente J" first="J." last="Valente">J. Valente</name></author><author><name sortKey="Deoreo, P" sort="Deoreo, P" uniqKey="Deoreo P" first="P." last="Deoreo">P. Deoreo</name></author><author><name sortKey="Weiss, M F" sort="Weiss, M F" uniqKey="Weiss M" first="M. F." last="Weiss">M. F. Weiss</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:32DFE19E92E0520491207A333C0F21B207AC134E</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1111/j.1492-7535.2004.0085f.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-QGDD64JP-N/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000804</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000804</idno><idno type="wicri:Area/Istex/Curation">000799</idno><idno type="wicri:Area/Istex/Checkpoint">001239</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001239</idno><idno type="wicri:doubleKey">1492-7535:2004:Schwing W:thrombotic:events:and</idno><idno type="wicri:Area/Main/Merge">002776</idno><idno type="wicri:Area/Main/Curation">002767</idno><idno type="wicri:Area/Main/Exploration">002767</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Thrombotic Events and Pentosidine in Hemodialysis</title><author><name sortKey="Schwing, W D" sort="Schwing, W D" uniqKey="Schwing W" first="W. D." last="Schwing">W. D. Schwing</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Case Western Reserve U, University Hospitals of Cleveland, and Centers for Dialysis Care, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Erhard, P" sort="Erhard, P" uniqKey="Erhard P" first="P." last="Erhard">P. Erhard</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Case Western Reserve U, University Hospitals of Cleveland, and Centers for Dialysis Care, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Holloman, C" sort="Holloman, C" uniqKey="Holloman C" first="C." last="Holloman">C. Holloman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Case Western Reserve U, University Hospitals of Cleveland, and Centers for Dialysis Care, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Weigel, K" sort="Weigel, K" uniqKey="Weigel K" first="K." last="Weigel">K. Weigel</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Case Western Reserve U, University Hospitals of Cleveland, and Centers for Dialysis Care, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Blankshaen, S" sort="Blankshaen, S" uniqKey="Blankshaen S" first="S." last="Blankshaen">S. Blankshaen</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Case Western Reserve U, University Hospitals of Cleveland, and Centers for Dialysis Care, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Anderson, J" sort="Anderson, J" uniqKey="Anderson J" first="J." last="Anderson">J. Anderson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Case Western Reserve U, University Hospitals of Cleveland, and Centers for Dialysis Care, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Siegel, C" sort="Siegel, C" uniqKey="Siegel C" first="C." last="Siegel">C. Siegel</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Case Western Reserve U, University Hospitals of Cleveland, and Centers for Dialysis Care, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Seaman, D" sort="Seaman, D" uniqKey="Seaman D" first="D." last="Seaman">D. Seaman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Case Western Reserve U, University Hospitals of Cleveland, and Centers for Dialysis Care, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Valente, J" sort="Valente, J" uniqKey="Valente J" first="J." last="Valente">J. Valente</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Case Western Reserve U, University Hospitals of Cleveland, and Centers for Dialysis Care, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Deoreo, P" sort="Deoreo, P" uniqKey="Deoreo P" first="P." last="Deoreo">P. Deoreo</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Case Western Reserve U, University Hospitals of Cleveland, and Centers for Dialysis Care, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Weiss, M F" sort="Weiss, M F" uniqKey="Weiss M" first="M. F." last="Weiss">M. F. Weiss</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Case Western Reserve U, University Hospitals of Cleveland, and Centers for Dialysis Care, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Hemodialysis International</title><title level="j" type="alt">HEMODIALYSIS INTERNATIONAL</title><idno type="ISSN">1492-7535</idno><idno type="eISSN">1542-4758</idno><imprint><biblScope unit="vol">8</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="80">80</biblScope><biblScope unit="page" to="80">80</biblScope><biblScope unit="page-count">100</biblScope><publisher>Blackwell Science Inc</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2004-01">2004-01</date></imprint><idno type="ISSN">1492-7535</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1492-7535</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Poorly functioning dialysis access, whether graft or AV fistula, is a contributor to decreased efficiency of dialysis. Thrombosis results in the need for surgery and increases patient suffering. Objectives: To determine whether an advanced glycation end product (AGE), pentosidine, might serve as a marker of disease activity and thrombosis of dialysis access. These results were obtained during the blinded phase of a study to evaluate the efficacy of the antioxidant vitamin E in preventing vascular access thrombotic events. Methods: Twenty‐six patients had blood drawn and access flow evaluated initially and at intervals for up to 1.5 years. In the study design, participants received either 800 IU vitamin E daily by mouth or identical placebo capsules. Blood plasma was examined to determine pentosidine content at baseline and every 3 m. Patients with an access flow of <800 mL/min were referred to a surgeon for evaluation. Access flow was evaluated by using the transonic flow meter and the saline release method. When sequential double dialyzers were used, saline injection method was applied post dialyzers, but before the venous drip chamber. Results: Mean initial level of pentosidine before the administration of vitamin E was 20.22 pmol/mg (range 5.04–59.62 pmol/mg). During the study period, 5 patients had procedures related to thrombosis performed on their accesses. Blood drawn before the thrombotic event showed an increase above baseline of 6.87 ± 15.47 (range −5.9 to +33.7 pmol/mg). Patients without events showed a mean decrease of 9.7 ± 12.24 pmol/mg pentosidine (p < 0.02). Conclusion: An increase in levels of pentosidine was associated with clotting of hemodialysis access. This change may reflect the effects of oxidative stress and/or thrombus formation. As these data are gathered from an ongoing double‐blinded study, the effect of vitamin E on thrombus formation and pentosidine levels has not yet been ascertained.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Schwing, W D" sort="Schwing, W D" uniqKey="Schwing W" first="W. D." last="Schwing">W. D. Schwing</name></region><name sortKey="Anderson, J" sort="Anderson, J" uniqKey="Anderson J" first="J." last="Anderson">J. Anderson</name><name sortKey="Blankshaen, S" sort="Blankshaen, S" uniqKey="Blankshaen S" first="S." last="Blankshaen">S. Blankshaen</name><name sortKey="Deoreo, P" sort="Deoreo, P" uniqKey="Deoreo P" first="P." last="Deoreo">P. Deoreo</name><name sortKey="Erhard, P" sort="Erhard, P" uniqKey="Erhard P" first="P." last="Erhard">P. Erhard</name><name sortKey="Holloman, C" sort="Holloman, C" uniqKey="Holloman C" first="C." last="Holloman">C. Holloman</name><name sortKey="Seaman, D" sort="Seaman, D" uniqKey="Seaman D" first="D." last="Seaman">D. Seaman</name><name sortKey="Siegel, C" sort="Siegel, C" uniqKey="Siegel C" first="C." last="Siegel">C. Siegel</name><name sortKey="Valente, J" sort="Valente, J" uniqKey="Valente J" first="J." last="Valente">J. Valente</name><name sortKey="Weigel, K" sort="Weigel, K" uniqKey="Weigel K" first="K." last="Weigel">K. Weigel</name><name sortKey="Weiss, M F" sort="Weiss, M F" uniqKey="Weiss M" first="M. F." last="Weiss">M. F. Weiss</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002767 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002767 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:32DFE19E92E0520491207A333C0F21B207AC134E
|texte= Thrombotic Events and Pentosidine in Hemodialysis
}}
| This area was generated with Dilib version V0.6.33. |  |